Molecular Determinants of Prostate Cancer Progression Across Race-Ethnicity

Abstract

This Prostate Cancer Center Initiation grant has been designed to identify genetic and molecular markers of prostate cancer progression within and between racial ethnic groups (African-Americans, Latinos, Whites, Japanese) at substantially distinct underlying risk of prostate cancer. Our Epidemiology Core has obtained signed tissue releases from 410 prostate cancer patients to date identified during follow-up of the Hawaii/Los Angeles Multiethnic Cohort study. One-hundred eight-five tissue samples have been received and processed histopathologically by Project C, which has begun immunohistochemical staining for p27, p21 and p16 markers with additional markers to follow. Project B, studying the androgen receptor (AR) gene in detail, has identified 21 sequence variants in 58 samples analyzed to date; one mutation was shown in culture to be twice as active as wild-type AR. In Project A, studying the SRD5A2 gene in detail, 24 sequence variants were found in 30 tumors with three mutations (A495, G692A and V63M occurring on a recurring basis.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2001
Accession Number
ADA394114

Entities

People

  • Ronald K. Ross

Organizations

  • University of Southern California

Tags

DTIC Thesaurus Topics

  • African Americans
  • Androgen Receptors
  • Biomedical Research
  • Cell Physiological Processes
  • Chemistry
  • Diseases And Disorders
  • Epithelial Cells
  • Ethnic Groups
  • Genetic Variation
  • Genetics
  • Health Services
  • Institutional Review Board
  • Medical Personnel
  • Mutations
  • Neoplasms
  • Prostate Cancer
  • Proteins

Readers

  • Aerospace Test and Evaluation
  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology