Signaling Mechanisms of Malignant Growth of Prostate Cancer Cells
Abstract
Prostate cancer is the most common malignancy and is the second leading cause of cancer death among males in the United States. Although androgen ablation has been the choice to treat prostate cancer, prostate cancer can recur and proliferate in androgen-deprival environment. Furthermore, androgen-independent prostate cancer cells are refractory to the hormone therapy and resistant to radiation and chemodrugs. Therefore, androgen-independent prostate cancer presents a major direct threat to patient survival. The molecular mechanisms underlying androgen-independent growth and apoptosis-resistance of malignant prostate cancer are still elusive. It is believed that dysregulation of the cellular survival and death signaling pathways may result in androgen-independent growth. This proposal is designed to investigate the role of the IkB kinase (IKK) signaling pathway, which is part of the cellular survival signaling machinery, in androgen-independent growth and apoptosis-resistance of prostate cancer cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2001
- Accession Number
- ADA394192
Entities
People
- Anning Lin
Organizations
- University of Chicago