Characterization of Novel Breast Cancer Specific Gene, BCSG1, in Human Breast Cancer Progression
Abstract
We recently identified and cloned a novel breast cancer-specific gene BCSG1 by direct differential cDNA sequencing. BCSG1 has a great sequence homology with Alzheimer disease (AD)-related neural protein synuclein, and thus was also named as synuclein gamma (SNCG). We demonstrated that: (1) SNCG expression was a stage-specific in human breast: undetectable in normal or benign breast lesions, low level and partial expression in low grade ductal carcinoma in situ but extremely high level in advanced infiltrating breast cancer; (2) SNCG expression in human breast cancer cells is dramatically suppressed by tumor growth inhibitor oncostatin M (OM), a cytokine predominantly produced by activated T cells and macrophages; and (3) overexpression of SNCG in breast cancer cells led to a significant increase in cell motility and invasiveness in vitro and a profound augmentation of metastasis in vivo. Our data suggest that the member of neural protein synucleins might have important functions outside the central nervous system and play a role in breast cancer progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADA394210
Entities
People
- Yiliang Liu