Elucidation of Pertussis Toxin-Sensitive Migration Signaling in Human Breast Cancer Cells
Abstract
The long range goal of this laboratory is to identify integrin-associated signaling events that contribute to the constitutive migration of human breast cancer cells on the laminin extracellular matrix proteins. This project has shown that the heterotrimeric G-protein G alpha i3 may link integrin activation and migration of MCF-10A cells via a cAMP signaling pathway. The focus of the remaining work on this project is to identify how each integrin subtype which binds laminin-1 contributes to the regulation of this and other pro- migratory signaling pathways.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2001
- Accession Number
- ADA394243
Entities
People
- William L. Rust
Organizations
- University of Nevada, Las Vegas