Novel Mechanisms by Which Estrogen Induces Antiapoptosis in Breast Cancer

Abstract

We have investigated the mechanisms by which estrogen serves as a survival factor for breast cancer, during chemotherapy or irradiation treatment in-vitro. UV irradiation for one minute or four hour treatment with taxol results in substantial apoptosis of breast cancer cell lines. This is due to a c-jun N-terminal kinase activation, leading to an inactivating phosphorylation of Bcl2 and Bcl(x-L) proteins, leading to caspase 9 activation and cell death. Estrogen blocks this proximally, at JNK activation. Independently, estrogen stimulates ERK MAP kinase activity which also contributes to cell survival. This was published in Molecular Endocrinology 14(9):1434-47, 2000.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2001
Accession Number
ADA394266

Entities

People

  • Ellis R. Levin

Organizations

  • University of California, Irvine

Tags

DTIC Thesaurus Topics

  • Blood
  • Breast Cancer
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Cytoskeleton
  • Health Services
  • Programmed Cell Death
  • Proteins
  • Vascular Diseases

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).