Permanent Implantation Brachytherapy for Prostate Cancer Using a Mixture of Radionuclides with Different Half Lives
Abstract
The project objective is to test whether the effectiveness of brachytherapy for prostate cancer can be improved by using a combination of short and long half life radionuclides simultaneously. Key research accomplishments in the past year are: (i) a theoretical model based on incomplete repair of radiation damage at low dose rates was developed for addressing the questions raised in the project; (ii) cell survival curves for both (125)I and (103)Pd were measured using monolayers of cells in a petri dish irradiated at low dose rates using (125)I and (103)Pd sources; (iii) an afterloading seed applicator was designed and fabricated in order to produce a consistent dose distribution to irradiate tumors transplanted to different animals and to minimize the radiation exposure to personnel handling radioactive seeds. In summary, we have made considerable progress towards the development of a theoretical model for continuous low dose rate irradiation using a mixture of radionuclides. Relative biological effectiveness of (125)I and (103)Pd at low dose rates in vitro was determined. An applicator for in vivo irradiations was designed and fabricated. Animal care procedures during the long low dose rate irradiations were developed. We are now ready to launch in vivo experiments with radioactive sources.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2001
- Accession Number
- ADA394344
Entities
People
- Ravinder Nath
Organizations
- Yale University