Nuclear Factor-kappa B is Not Up-Regulated in Rat Pulmonary Tissue Following Sulfur Mustard (HD) Exposure

Abstract

Vesicants, such as sulfur mustard (HD), pose an insidious threat to the respiratory tract. Exposure causes acute lung injury characteristic of an inflammatory response. Nuclear Factor-KAPPA B (NF- square B) is a redox sensitive transcription factor important in regulating genes involved in the inflammation. This study evaluated levels of NF-square B following exposure to HD. Male rats were euthanized at 3, 6, or 24 hr following intravenous HD or isopropanol (IPA controls) exposure. Nuclear protein samples extracted from pulmonary tissue were analyzed using an electrophoretic mobility shift assay.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2001
Accession Number
ADA395218

Entities

People

  • Alfred M. Sciuto
  • James A. Blank
  • Kristi L. Buxton
  • Michele M. Danne
  • Nancy A Niemuth

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Animals
  • Biological Sciences
  • Biomedical Research
  • Body Weight
  • Cells
  • Chemical Synthesis
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Free Radicals
  • Inflammation
  • Oxidative Stress
  • Proteins
  • Rodents
  • Statistical Analysis
  • Sugar Alcohols
  • Transcription Factors

Fields of Study

  • Biology

Readers

  • Geochemistry
  • Molecular and genetic basis of cancer.
  • Trauma Surgery or Emergency Medicine.