Effects of Sodium 2-Mercaptoethanesulfonate (Mesna) as a Post-Treatment in Mice Challenged With Phosgene

Abstract

The effects of 2-mercaptoethanesulfonate (mesna) as a post-treatment against exposure to a lethal dose of phosgene (CG) were investigated. Mesna appears to be a potential candidate against phosgene-induced injury because it may increase sulfhydryl concentrations, which may reduce cellular injury. Mice were exposed to phosgene, 32 mg/m(3) , or air for 20 minutes. After a 5-minute washout with air, mice were injected interperitoneally (ip) with 0, 334, 834 or 1,667 mg/kg of mesna or phosphate buffered saline (PBS) at 20 minutes, 2, 5, 8 and 11 hours. Survival was assessed every 2 hours for 12 hours and at 24 hours. Lungs were removed and analyzed for wet weight, dry weight, wet/dry ratio, protein, and non-protein sulfhydryls (NPSH).

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2001
Accession Number
ADA395225

Entities

People

  • Alfred M. Sciuto
  • Jeffry S. Forster
  • Mathew P. Cascio
  • Steven I. Baskin
  • Theodore S. Moran

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Animals
  • Army Training
  • Biological Sciences
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cells
  • Cysteine
  • Immune System
  • Infrared Spectrometers
  • Laboratory Animals
  • Lethal Dosage
  • Lung Diseases
  • Measurement
  • Military Research
  • Survival
  • Tissues

Fields of Study

  • Medicine

Readers

  • Solar Photovoltaics and Thermoelectric Devices.
  • Toxicology/Environmental Toxicology