A Cutaneous Full-Thickness Liquid Sulfur Mustard Burn Model in Weanling Swine: Clinical Pathology and Urinary Excretion of Thiodiglycol
Abstract
Sulfur mustard (bis(2-chloroethyl)sulfide, HD) is a well-known blistering chemical warfare agent. We have developed a cutaneous full-thickness HD burn model in weanling pigs for efficacy testing of candidate treatment regimens. This report addresses clinical pathology findings and the urinary excretion profile of a major HD metabolite (thiodiglycol, TDG) in this model. Six female Yorkshire pigs were exposed to HD liquid on the ventral surface for 2 h, generating six 3-cm diameter full-thickness dermal lesions per pig. Blood samples were collected throughout a 7-day observation period for hematology and serum chemistry examinations. Urine was collected in metabolism cages. Routine urinalysis was performed and the urine analyzed for TDG .
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2000
- Accession Number
- ADA395226
Entities
People
- F. S. Tucker
- Frances M. Reid
- John S. Graham
- Joseph P. Smith
- Nancy A Niemuth
- Richard R. Stotts
- Shawn M. Shumaker
- Stephen J. Janny
Organizations
- United States Army Medical Research Institute of Chemical Defense