Molecular Mechanisms of Dietary Fatty Acids on Breast Cancer Growth and Development
Abstract
The link between diet and breast cancer has been long postulated and recently, extensively investigated. Identifying a molecular mechanism linking diet and breast cancer, however, has remained elusive. Recently, we identified an isoform of the cellular receptor called the peroxisomal proliferator-activated receptor (PPAR) in several human breast cancer cell lines. Activation of PPAR can alternatively lead to tumor induction or differentiation into a more benign state, depending on the tissue and the isoform expressed. We and others have demonstrated that human breast cancer cell lines express PPAR__ and that individual fatty acids are capable binding to and functioning as selective agonist or antagonist of PPAR.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2001
- Accession Number
- ADA395514
Entities
People
- Michael W. Kilgore
Organizations
- University of Kentucky