New Rhenium Radiopharmaceuticals for the Selective Imaging and Therapy of Breast Cancer

Abstract

Several novel rhenium-estradiol complexes were synthesized as potential radiopharmaceuticals for the imaging and therapy of breast cancer. Novel palladium catalyzed carbon-carbon and carbon-nitrogen bond-forming chemistry was developed to synthesize phenyl and pyridyl hydrazine derivatives. Polymer-supported hydrazine derivatives were effective labeling substrates for synthesizing organoimidorhenium estradiol complexes. The estradiol-rhenium complexes were fully characterized structurally. The solubility and stability of the organoimidorhenium complexes in aqueous systems was investigated. Pyridylhydrazine derivatives of estradiol were found to form stable rhenium(I) carbonyl complexes, and are excellent candidates for continued investigation as diagnostic and therapeutic radiopharmaceuticals for breast cancer.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2001
Accession Number
ADA396163

Entities

People

  • Jeffrey B. Arterburn

Organizations

  • New Mexico State University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Hydrazine Derivatives
  • Hydrazines
  • Materials
  • Metals
  • Neoplasms
  • Nuclear Medicine
  • Organic Chemistry
  • Radiotherapy

Fields of Study

  • Chemistry

Readers

  • Oncology (Cancer Research).
  • Organic Chemistry