Characterization of a Putative Tumor Suppressor in Breast Cancer
Abstract
The RASSFlA locus is epigenetically inactivated in most lung and breast tumors. Expression of RASSFlA is sufficient to revert the growth transformation of human tumor cell lines. We show here that RASSFlA engages the Rb-family cell cycle checkpoint by inhibiting accumulation of cyclin Dl protein. Rare alleles of RASSFlA, isolated from tumor cell lines, encode proteins with alterations that block phosphorylation of RASSFlA on a putative ATM kinase phosphorylation site. These RASSFlA variants cannot inhibit proliferation of tumor cell lines, and suggest that RASSFlA activity is regulated by protein kinase cascades.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2001
- Accession Number
- ADA396348
Entities
People
- Latha Shivakumar
Organizations
- University of Texas at Dallas