FCCC Institutional Breast Cancer Training Program
Abstract
During the first year of our Institutional Breast Cancer Research Training Program at the FCCC we have recruited, from a pool of 26 applicants, four trainees (Drs. Lareef, Sherman, Zalatoris and Pan). Four main areas of research are m progress. Dr Lareef is studying the functional role of chromosomes 11 and 17 in the process of immortalization and transformation of human breast epithelial cells. Transfer of chromosome 17 in to transformed human breast epithelial cells (BPl-E) reverts the transformation phenotypes and the Fas mediated apoptosis. The gene or genes that are controlling this process are located in the chromosome l7pl3. l.l3.2(Dl7S796). Dr. Sherman has initiated the study on lymphedema prevention in breast cancer survivors. Dr. Zalatoris is studying the polymorphisms of human UGTlA6 and UGTlA9 genes and functional differences of the variant gene products. Dr. Pan is studying the role of upsilon-synuclein in breast cancer progression and metastasis. He has identified ERKl/2 and JNK as protein kinases interacting with upsilon-synuclein and determining that the interaction between ERKl/2 and upsilon-synuclein is independent of the activation status of ERKlI2. Lastly he has shown that stress-induced (i.e., UV radiation, heat shock, and sodium arsenite) JNK activation can be specifically blocked by upsilon-synuclein.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA396378
Entities
People
- Jose Russo
Organizations
- Fox Chase Cancer Center