Insulin Like Growth Factor I Receptor Function in Estrogen Receptor Negative Breast Cancer

Abstract

The development of estrogen receptor (ER) negative breast cancer is associated with development of alternate growth regulatory pathways. Three in vitro models of ER+ and ER- breast cancer were evaluated for expression and activation of MAP kinase and p70/S6 kinase as possible growth regulators in ER-breast cancer. Despite decreased activity of MAP kinase in ER-cells, growth of these cells is entirely dependent on signaling through MAP kinase as determined by analyzing growth in the presence of UO126, A MAP kinase inhibitor. Even though activity of p7O/S6 kinase is maintained in ER- cells, growth is not affected by inhibition of p70/S6 kinase. These results suggest that signaling through the Ras/Raf/MAP kinase pathway is critical for the growth of ER- breast cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA396388

Entities

People

  • Michele K. Doughterty

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Estrogens
  • Growth Factors
  • Inhibition
  • Inhibitors
  • Kinases
  • Microarray Analysis
  • Neoplasms
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.