Estrogens, Microtubules and Aneuploidy: Mechanisms of Mammary Gland Tumorigenesis

Abstract

This project assesses possible mechanisms of tumorigenesis for estradiol and related estrogens. The intent is to use mammary epithelial cells (MEC) from rat strains which differ markedly in their susceptibility to estrogen carcinogenicity. The hypothesis to be tested is that MEC from the sensitive strain will show increased sensitivity to microtubule disruption and the induction of aneuploidy by estrogens than will the cells from the resistant strain. This hypothesis has not been tested in the past year, and the author has tried repeatedly to obtain authorization for a new year no-cost extension of the project.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA396400

Entities

People

  • Gregory A. Reed

Organizations

  • University of Kansas Medical Center

Tags

DTIC Thesaurus Topics

  • Acetic Acid
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Environmental Health
  • Epithelial Cells
  • Estrogens
  • Genetics
  • Glands
  • Hormones
  • Liquid Chromatography
  • Mammary Glands
  • Medical Personnel
  • Microsomes
  • Pharmacology
  • Therapy

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
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  • Toxicology/Environmental Toxicology