Genes Controlling Susceptibility to Mammary Cancer

Abstract

This work examined the response of different genotypes of mice to the carcinogen 7,l2-dimethylbenzAanthracene (DMBA). Mice demonstrate a genotypic specificity for the particular tumors that they develop; DMPA increase the incidence of and decreases the average age at which these tumors are manifest. It does not appear that the genetic instability of the sort associated with the Werner syndrome in humans appreciably enhances the predilection of mice to develop mammary cancer, even in mice dosed with the carcinogen DMBA. Increased adiposity is a risk factor for postmenopausal breast cancer in humans. Data is presented demonstrating that the dietary intervention of calorie restriction reduces the incidence of mammary tumors following carcinogen administration in genotypes predisposed to its development.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA396452

Entities

People

  • Ruth Lipman

Organizations

  • Tufts University

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Breast Cancer
  • Cells
  • Chemistry
  • Chromosomes
  • Digestive System Processes
  • Diseases And Disorders
  • Drug Therapy
  • Gene Expression
  • Genetic Structures
  • Genetics
  • Health Services
  • Medical Personnel
  • Neoplasms

Fields of Study

  • Biology

Readers

  • Exercise and Sports Science.
  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology