The Role of Vasculogenesis in Breast Cancer
Abstract
Tumor growth, progression, and metastasis are dependent on the ability of the tumor to recruit a blood supply. It is currently believed that tumors become vascularized by a process referred to as angiogenesis. We propose that a second process of blood vessel formation, vasculogenesis, a process not currently associated with tumor vascularization, is operative in breast cancer. Although it is well established that all new blood vessels are formed by either angiogenesis or vasculogenesis, it is believed that only angiogenesis, the formation of new blood vessels from existing blood vessels, occurs in adults. Recent evidence suggests that this may not be the case and that vasculogenesis, a process currently associated with the formation of blood vessels in the embryo, is operative in adults. That vascularization is supported by experiments that suggest that mesodermally derived stem cells are found at sites where new blood vessels are forming in adults. If we are correct that the vessels of the rumor are in part or fully formed by vasculogenesisi, then our knowledge of this process, which has mechanisms that are distinct from angiogenesis could be used to combat the progression of the breast tumor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA396464
Entities
People
- Christopher J. Drake
Organizations
- Medical University of South Carolina