Natural History of Breast Density and Breast Cancer Risk
Abstract
Over the past year, we have selected 123 breast cancer cases diagnosed 1997-1999 and 217 matched controls from the mammography database at the Mayo Clinic. Controls were matched to cases on age, race, menopausal status, distribution of mammograms and month of last appointment for mammogram. All mammograms over the last 10 years were obtained on these women, digitized, and stored in a format that can be read by our breast density estimation software. Risk factor information was abstracted from charts on all these women, including weight information at times of mammograms, hormone replacement therapy use, tamoxifen, raloxifene medications, family history, alcohol and smoking information. We will obtain parity and age at first birth from the mammography database. We have estimated breast density on the oldest mammogram from both cases and controls, using our semi-automated software and using a subjective categorical estimate. We have begun preliminary analyses to examine the association of percent breast density and absolute dense area (using the oldest mammogram) with breast cancer risk. Next winter, we will continue these analyses investigating the change in density over time and breast cancer risk. Also, we will continue to retrospectively identify and collect breast cancer cases and controls from the mammography database. Our goal is to collect at least 200 cases and 400 controls over the next two years.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA396527
Entities
People
- Celine M. Vachon
Organizations
- Mayo Clinic