Evaluation of Response to Induction Therapy in Breast Cancer With Phosphorus-31 Magnetic Resonance
Abstract
The objective of the proposed research is to develop 15-decoupled 31P magnetic resonance spectroscopy (MRS) techniques for measuring non-invasively the response of breast cancer to induction or preoperative chemotherapy. We hypothesize that the quantitative assessment of the effectiveness of a treatment using 31P MRS will be clinically feasible at 3.0T. To validate our approach, we propose first, to perform measurements using appropriate standards and, second, a pilot study including women with breast cancer undergoing induction chemotherapy. During the first year of funding, a prototype double tuned proton/31-phosphorus transmit-receive coil has been built. The coil has been tested at 3.0T (proton frequency: 123.23 MHZ; 31-phosphorus: 49.89 MHz) by using standards containing compounds of interest (phosphorylethanolamine, inorganic phosphate and 5-adenosine triphosphate).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2001
- Accession Number
- ADA396564
Entities
People
- Leoncio Garrido
Organizations
- Massachusetts General Hospital