Cell Migration as a Therapeutic Target in Malignant Breast Cancer
Abstract
The object of this project is to develop a high-throughput method for screening potential inhibitors of breast cancer cell haptotaxis and chemotaxis, and to apply this method to identify signaling events mediating constitutive migration of malignant breast cells. The pathways that control these signaling events may be targets for development of new classes of anti-tumor drugs. The significant advances made during the third year of the project include generation of laminin-1 fragments for examining-integrin-specific adhesion and signaling and identification of rho-A as a target for the migration inhibitory compound perillyl alcohol. The significance of this work is demonstration of the utility of the novel migration inhibitor drug screen we have developed, plus development of reagents that will enable us to examine the signaling associated with specific integrin complexes in breast cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADA396567
Entities
People
- George E. Flopper Jr
Organizations
- University of Nevada, Las Vegas