Functional Analysis of the ErbB4 Receptor Tyrosine Kinase
Abstract
This IDEA award is supporting our efforts to elucidate the roles that the ErbB4 receptor tyrosine kinase plays in breast cancer. We have generated three constitutively active mutants of ErbB4. Unlike constitutively active ErbB1 or ErbB2 mutants, the constitutively active ErbB4 mutants DO NOT couple to increased cell proliferation, to anchorage independent growth, or to a loss of contact inhibition in rodent fibroblast cell lines. Moreover, at least one of the constitutively active ErbB4 mutants is coupled to inhibition of colony formation in human mammary (tumor) cell lines and to inhibition of mammary (tumor) cell line proliferation. This suggests that ErbB4 is coupled to mammary tumor suppression in vivo.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA396641
Entities
People
- David J. Riese
Organizations
- Purdue Research Foundation