Caspase Deficiency: Involvement in Breast Carcinogenesis and Resistance

Abstract

Apoptosis (programmed cell death) is a fundamental process involved in homeostasis and the biological response to anti-tumor therapy. Aberrant expression of apoptotic regulators, such as Bax-a, Bcl-2 and p53 has been associated with breast cancer carcinogenesis and therapeutic resistance. Apoptosis is mediated by caspases, groups of proteases. We and others have shown that caspase 3, an effector caspase, is deficient in MCF-7 breast cancer cell line. This project was designed to study the incidence and significance of caspase deficiency in breast cancers.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA396661

Entities

People

  • Xiaohe Yang

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Blood
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemotherapeutic Agents
  • Chemotherapy
  • Culture Techniques
  • Diseases And Disorders
  • Ionizing Radiation
  • Neoplasms
  • Oncology
  • Programmed Cell Death
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).