Environmental Exposures at Birth and at Menarche and Risk of Breast Cancer
Abstract
This is a population-based study that examines location of residence during the period between birth and menarche in relation to proximity to industrial sites, gasoline stations, toxic waste sites and heavily trafficked roadways as risk factors for subsequent breast cancer. We also will examine estimated exposure to benzene and PAHs as risk factors and evaluate genetic susceptibility in relation to these exposures and breast cancer. To date addresses for approximately 2,682 participants have been entered, and 200 participants' addresses have been geocoded using a Geographic Information System (GIS). 1,740 blood samples were sent for DNA extraction and genotyping. A validation study for geocoding was conducted to choose an efficient mapping tool, to determine accuracy of matched addresses, and to determine reasons for address matching failures. Based on the validation study, GDT/Dynamap will be used to geocode addresses in this study; ZP4 software and Polk Directories will be used to clean address data and to find missing residential information. We are just beginning to examine possible sources for the exposure assessment including aerial photographs of the study area, water sources, industrial directories, and the EPA hazardous waste site list.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2001
- Accession Number
- ADA396674
Entities
People
- Jo L Freudenheim
Organizations
- University at Buffalo