Functional Analysis of the ErbB4 Receptor Tyrosine Kinase
Abstract
This career development award is supporting a multi-faceted, multidisciplinary approach to elucidate the roles of EGF (epidermal growth factor) family hormones and ErbB receptors in breast cancer and to develop novel strategies to target these hormones and receptors. We have four major efforts underway. (1) We have been assaying novel quinazolines and analogs of lavendustin A for inhibition of EGFR tyrosine kinase activity. The goal is to identify potential breast tumor imaging agents and breast tumor chemotherapeutics that target the EGFR. (2) We have constructed a constitutively active mutant of the ErbB4 receptor tyrosine kinase. The activities of this mutant suggest that ErbB4 may be coupled to mammary tumor cell growth arrest and mammary tumor suppression. (3) We have identified the ErbB family receptors that are activated by four novel EGF family hormones. This is the first step in determining the role that these hormones may play in mammary tumorigenesis. (4) We have identified amino acid residues in the EGF family hormone Neuregulin 2beta that are critical for activation of ErbB4 signaling by this hormone. This is the first step in developing potential breast cancer therapeutics that specifically target ErbB4.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA396708
Entities
People
- David J. Riese
Organizations
- Purdue Research Foundation