Genetic Susceptibility to Cancer Chemotherapy in Human Breast Cancer
Abstract
We have focused on the ability to predict responsiveness to tubulin targeting chemotherapeutic drugs by understanding the role of p53 repression on the expression of proteins that regulate microtubule dynamics. We previously demonstrated that repression of microtubule associated protein 4 (MAP-4) produced tubulin depolymerization sensitivity to vinca alkaloids, and resistance to taxanes. We built on this observation to design a phase I clinical trial to determine if this could be accomplished in and confirmed fl%the ability to produce this effect in several human specimens. At the same time we studied the repression of stathmin, a cytosolic phosphoprotein which binds to and stabilizes tubulin heterodimers. Stathmin appears to be more sensitive to repression by p53 than MAP-4 and may lead to additional approaches to treatment of patients with breast cancer during the next grant period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2000
- Accession Number
- ADA396823
Entities
People
- William Hait