Therapeutic and Chemopreventive Actions of a Novel Polywmine Analog Against Breast Cancer

Abstract

The intracellular polyamines, spermidine, spermine, and putrescine, play an important role in the proliferation and death of normal and malignant cells. As a consequence, our work has focused on development of inhibitors of this metabolic pathway. A phase II trial of diethylnorspermine (DENSpm) for women with advanced breast cancer has enrolled 16 patients. Analysis of clinical outcome is in progress and no excessive toxicity has been observed. Collection of DENSpm- and control-treated breast cancer tissues derived from discarded mastectomy tissues has continued. Testing of polyamine analogs as treatment for established breast cancer is in progress using the nude mouse xenograft model. Proposed chemoprevention studies will begin as soon as the therapy studies are complete.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADA396921

Entities

People

  • Nancy E. Davidson

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amines
  • Biomedical Research
  • Breast Cancer
  • Classification
  • Clinical Trials
  • Electronic Mail
  • Information Operations
  • Maryland
  • Monitoring
  • Neoplasms
  • Schools
  • Security
  • Universities

Fields of Study

  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology