Novel Peptide/Protein Delivery System Targeting erbB2-Overexpressing Breast Cancer Cells
Abstract
It has been well recognized that the next frontier in molecular medicine is the delivery of therapeutics. Among the biological therapeutics, peptides/proteins are especially difficult and challenging to deliver. A peptide sequence localized within a 13-amino acid domain of Tat (named "penetratin"), when linked to other peptides or proteins, was able to carry attached peptide or protein into the cells when they were added to cell culture medium. We hypothesized that the unique property of "penetratin" can be utilized for delivery of therapeutic peptides/proteins. It should be noted that after the funding of this Idea Award, a report published in Science by Steven Dowdy's laboratory demonstrated that "penetratin" can deliver functional beta-galactosidase protein (120 kD) to all tissues in mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2001
- Accession Number
- ADA397007
Entities
People
- Dihua Yu
Organizations
- The University of Texas MD Anderson Cancer Center