Ubiquitin Pathway Enzymes: Coactivators of Nuclear Hormone Receptors and Their Role in the Development of Breast Cancer

Abstract

Steroid hormones, estrogen and progesterone, and their intracellular receptors play an important role in the development and progression of breast cancer. Coactivator proteins modulate the biological activity of these hormone receptors. We have cloned an E3 ubiquitin-protein ligase enzyme, E6-associated protein (E6-AP) and E2 ubiquitin conjugating enzyme, UbcH7 as coactivators of steroid hormone receptors. The purpose of this research is to explore the possibility that the altered expression of E6-AP and UbcH7 may contribute to the development of breast cancer. We have examined this possibility by studying the expression patterns of E6-AP, UbcH7 and estrogen receptor-alpha (ER) in various human breast cancer cell lines and breast tumor biopsy samples. Additionally, we have correlated the expression profile of E6-AP and UbcH7 with that of ER in breast tumor biopsies.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA397349

Entities

People

  • Zafar Nawaz

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Androgen Receptors
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Epithelial Cells
  • Hormones
  • Mammary Glands
  • Molecules
  • Neoplasms
  • Papillomavirus Infections
  • Proteins
  • Tissue Extracts
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.