Novel Resuscitation from Lethal Hemorrhage. Increasing Survival of Combat Casualties
Abstract
Using our novel animal models of severe hemorrhage, focusing on evaluation of outcome to 3-10 days, the following strategies were found superior in terms of intact survival compared to standard resuscitation. Project I on hemorrhagic shock revealed benefit from limited (hypotensive) titrated fluid resuscitation; mild hypothermia during shock and resuscitation; additional use of antioxidant tempol i.v. or intraperitoneal; titrated i.v. administration (instead of bolus) of hypertonic/nyperoncotic solution for preventing cardiac arrest during uncontrolled hemorrhagic shock; and peritoneal oxygenation and medication. Program II on "suspended animation" was In novel animal models of severe hemorrhage to cardiac arrest (no blood flow). the prevalent cause of death in combat.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2001
- Accession Number
- ADA397518
Entities
People
- Peter Safar
- Samuel A. Tisherman