Risk Factors for Chorioamnion Infection and Adverse Pregnancy Outcome Among Active-Duty Military Women and Dependent Women
Abstract
Cervicovaginal ureaplasmal infection alone is not predictive of preterm birth. Only a subpopulation of women infected in the lower genital tract are at risk for chorioamnion invasion and premature birth. The major goal of this study was to identify microbiologic factors that may predispose to and/or predict chorioamnion invasion and premature birth. Specifically, we sought to determine if the presence of bacterial vaginosis (Bv) was a risk factor for ureaplasmal invasion of the chorioamnion. At the first prenatal visit, cervicovaginal ureaplasmal colonization nor BV alone were predictors of chorioamnion invasion but women colonized with both ureaplasma and BV were 2.8 times more likely to have an intrauterine fetal demise. We also sought to determine if ureaplasma chorioamnion colonization was associated with premature birth in active duty military personnel and whether this explains the observed difference in the rate of prematurity between active duty and dependent women. After controlling for all variables in the multivariate analysis, enlisted women were 2.4 times more likely to have a preterm birth < 34 weeks than women that were not enlisted. However, chorioamnion infection did not explain the differences. Results from this study have given us a comprehensive analysis of the incidence of sexually transmitted pathogen% in pregnant women in the Navy. Future work will include that speciation of ureaplasma isolates to determine if virulence of one speciesis predictive of chorioamnion invasion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2001
- Accession Number
- ADA397622
Entities
People
- Gail Cassell
Organizations
- University of Alabama