Control of Expression of Insulin-Like Growth Factor II in Stromal Cells of Breast Cancer

Abstract

Our hypothesis is that the IGF2 gene is methylated in normal breast stromal cells, and that a decrease in methylation results in increase in stromal IGF2 expression in the breast malignancy, enhancing tumor growth. This work analyzes the biochemical mechanisms that alter methylation of the IGF2 promoter in benign stromal cells adjacent to the malignant epithelial cells in the breast tumor. The studies of this project were conducted in two systems: T6 1 breast cancer system, an ER+, PR+, IGF2 expressing breast cancer xenograft passaged in nude mice, and matched fibroblast sets from breast cancer patients. These studies could provide critical insight into stromal regulation of breast cancer and provide a new target for therapy.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2001
Accession Number
ADA397706

Entities

People

  • Sahana S. Kaup

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Epithelial Cells
  • Fibroblasts
  • Gene Expression
  • Growth Factors
  • Methylation
  • Neoplasms
  • Regulations
  • Stromal Cells
  • Tissues

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).