Signal Transduction in Prostate Cancer

Abstract

The goal of this Prostate Cancer Center Initiation Award is to examine signal transduction pathways involved in prostate cancer progression, with an eye toward transitional research applications. The current funded program has two Projects and a Core Animal Facility. The first project, directed by DL Carey, is focused on crosstalk between receptor tyrosine kinases and the androgen receptor (AR), using the Her2/neu kinase as a model system. The second project, directed by Dr. Cohen, examines the role of IGF binding protein 3 (IOFBP-3) in tile context of crosstalk with the retinoic acid co-receptor RXR alpha.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2001
Accession Number
ADA398040

Entities

People

  • Charles Sawyers

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Apoptosis
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Chemical Synthesis
  • Chemistry
  • Growth Factors
  • Hormones
  • Inhibitors
  • Mass Spectrometry
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Spectrometry

Fields of Study

  • Physics

Readers

  • Breast cancer cell signaling and growth regulation.
  • Prostate Cancer Biology.
  • Technical Research and Report Writing.