Apoptosis in Prostate Cancer

Abstract

To develop new therapeutic means to treat androgen independent prostate cancer, we hypothesized that the apoptotic pathway of prostate cancer cells can be manipulated for therapeutic purposes. In support of our hypothesis, we presented preliminary data showing that a molecule of the apopotic pathway, caspase 7, induced therapeutic apoptosis after adenoviral-mediated overexpression. This was observed in vitro in LNCaP and LNCaP-Bcl-2 cells, and in vivo in the prostate of normal mice, which were inoculated with a virus overexpressing caspase-7 under the control of the powerful viral promoter RSV (AvC7).

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2001
Accession Number
ADA398042

Entities

People

  • Marco Marcelli

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Androgen Receptors
  • Antineoplastic Agents
  • Apoptosis
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Gene Therapy
  • Health Services
  • Molecules
  • Neoplasms
  • Programmed Cell Death
  • Prostate
  • Prostate Cancer
  • Tissues

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).
  • Prostate Cancer Biology.