Development for Dual Acting Inhibitors for Breast Cancer

Abstract

To design dual acting inhibitors that can block the enzyme estrone sulfatase (an enzyme involves in the in situ formation of estrogen in breast cancer cells) and act as antiestrogens. Scope: The design and synthesis of 30 dual inhibitors are proposed. The inhibitors contain 4 different structural core. The synthesized inhibitors will be tested on their ability to inhibit the enzyme estrone sulfatase and also their ability to inhibit the growth of breast cancer cells stimulated by estrone sulfate. In addition, selected inhibitors will be tested in vivo using NMU-induced mammary tumors in rats.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2001
Accession Number
ADA398105

Entities

People

  • Pui-kai Li

Organizations

  • Ohio State University

Tags

DTIC Thesaurus Topics

  • 1-Ring Heterocyclic Compounds
  • Alkenes
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Cellular Structures
  • Chlorides
  • Estrogens
  • Imidazoles
  • Inhibition
  • Inhibitors
  • Lead Compounds
  • Microsomes
  • Neoplasms
  • Substrates
  • Sulfamates

Readers

  • Breast cancer cell signaling and growth regulation.