MR Imaging and Gene Therapy of Breast Cancer
Abstract
This grant is a Career Development Award. Since this very first funding award to the P.I., I have successfully obtained some other grants, either serving as the P.I. or Investigator. The training experience was very important for me to become a competitive investigator. MR imaging was applied to longitudinally monitor the tumor volumetric changes as well as the vascular changes. The histological examination technique was developed to quantitatively measure the vascular area from the H&E staining tumor slides. We also assessed the degree of inflammation in the tumor. In Yr-O3 we studied 48 tumors with MRI. The baseline study was first performed, then the adenoviruses carrying different genes were injected intratumorally. Five days later the follow-up MRI study was performed to determine the growth rates. The tumors were then excised for histological analysis to determine the vascular area and the inflammation scale. We found that the MRI volumetric or vascular properties could not reliably predict the tumor growth, however, it can be used as a suitable monitoring modality. We further attempted to correlate the MRI findings with the underlying biological changes, including vascularity and inflammation. However, no significant correlation was found. Nevertheless, the techniques that were developed in this project can be applied to other projects in the future.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA398125
Entities
People
- Min-ying Su
Organizations
- University of California, Irvine