FC-Gamma Receptor-Targeted Immunization for Breast Cancer

Abstract

The objective of this research project is to test the hypothesis that immune responses to a cancer antigen that is commonly overexpressed in breast cancer can be selectively enhanced and lead to protection against such tumors. This hypothesis of Fc-gamma receptor-targeted immunization is being tested through the construction of fusion proteins containing a fragment of the extracellular domain of the HER2/neu antigen and an antibody Fc-gamma domain. The resulting fusion protein should target an immunogenic and tumor growth modulatory epitope of HER2/neu to antigen-presenting cells via Fc-gamma receptors.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2001
Accession Number
ADA398127

Entities

People

  • Louis M. Weiner

Organizations

  • Fox Chase Cancer Center

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Construction
  • Immunity
  • Immunization
  • Immunoglobulins
  • Macromolecules
  • Molecules
  • Neoplasms
  • Pcr Testing
  • Polymers
  • Proteins

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Immunology