Phase I Induction and Estrogen Metabolism in Women With and Without Breast Cancer and in Response to a Dietary Intervention

Abstract

This combined case-comparison study and randomized controlled trial (RCT) of 90 women is based on our prior epidemiologic work (1-6) indicating that vegetables in the Brassica genus (e.g., broccoli, cauliflower, brussel sprouts) can modify estrogen metabolism by causing l7-beta- Estradiol (E2) to be metabolized to 2-hydroxyestrone (2HE) rather than 16-alpha-hydroxyestrone (l6HE) thus producing a cascade of effects protective against breast cancer (2). Our plan is to enroll 45 postmenopausal women with breast cancer and 45 age- matched disease-free women and to compare them on: 1) AhR activation and its various protein products relevant to cancer including CYP1B1, PAl-2, and IL-1; and 2) levels of relevant estrogens, E2, 2HE, and 16HE. The RCT will examine the effect of an intensive Brassics-rich diet intervention on AhR activation, its protein products, and estrogen metabolites in these women. This study is beginning its second full year of funded activity. All protocols for the collection of data are finalized and we have begun to recruit participants. The baseline data are being collected for case-comparison study and the first of four intervention cycles for the RCT will begin early in 2002. Specific accomplishments are described in the following narrative, in parallel with the original Statement of Work. Fowke JH, Longeope C, Hebert JR. Macronutrient intake and estrogen metabolism in healthy postmenopausal women. Breast Cancer Res Treat 2001;65:1-10. 2. Fowke JH, Longeope C, Hebert JR. Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer Epidensiol Biomark Prev 2000; 9:773-779. 3. Hebert JR, Hueley TO, Ma Y. The effect of dietary exposures on recurrence and mortality in early stage breast cancer. Breast Cancer Res Treat 1998; 51:17-28 4. Hebert JR, Rosen A. Nutritional, socioeconomic, and reproductive factors in relation to female breast cancer mortality:

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2001
Accession Number
ADA398128

Entities

People

  • James R Hébert

Organizations

  • University of South Carolina

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Breast Cancer
  • Chemistry
  • Colon Cancer
  • Databases
  • Health Services
  • Liquid Chromatography
  • Meals
  • Medical Personnel
  • Neoplasms
  • Nutritional Sciences
  • Side Effects
  • Therapy
  • Two Dimensional
  • Vegetables

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