Immunotherapy of Breast with Tumor RNA Transfected Dendritic Cell Vaccines
Abstract
The major research focus of this grant is to develop effective treatments for patients with low volume metastatic disease using dendritic cell (DC)-based vaccines loaded with tumor RNA. Toward this goal, during the third year of this grant we have made the following progress: 1) We developed a highly improved antigen-presenting platform to stimulate anti-tumor immunity. It involves two major improvements, a) Development of methods to mature DC and b) Electroporation of RNA into DC. 2) Extensive discussions with FDA toward approval of an IND to treat breast cancer patients with amplified tumor RNA-using mature electroporated DC-as described in Specific Aim #4, the major objective of this grant.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADA398155
Entities
People
- Eli Gilboa
Organizations
- Duke University Hospital