In Vivo Testing of Chemopreventive Agents Using the Dog Model of Spontaneous Prostate Carcinogenesis
Abstract
The goal of this research was to demonstrate the feasibility of the dog model of spontaneous prostate carcinogenesis as a valuable animal model system to evaluate potential chemopreventive agents. Specifically, we sought to determine if androgen deprivation, or supplementation with dehydroepiandrosterone (DHEA) or selenium modulates biomarkers of prostate carcinogenesis in elderly male dogs. To accomplish this, we conducted a 6 month laboratory intervention trial using 49 purchased elderly intact male beagle dogs randomly assigned to 1 of 5 treatment groups: (1) no treatment; (2) 3 micrograms/kg selenomethionine PO; (3) 6 micrograms/kg selenomethionine PO; (4) DHEA 100 mg/kg PO; or (5) surgical castration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2001
- Accession Number
- ADA398171
Entities
People
- David J. Waters
Organizations
- Purdue Research Foundation