Molecular Basis of Natural Killer Cell Tumor Target Recognition: The NKr/MHC Class I Complex

Abstract

The original goal was to purify both NK cell receptor molecules (Ly49C) and cognate class I MHC ligands (H2-Kb) to determine the crystal structure of Ly49C bound to K(b). Others using Ly49A and H2-D(d) solved this aim. Therefore we chose to test the effect of blocking' receptor-class I interactions on killing of tumor cells by host NK cells.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2001
Accession Number
ADA398189

Entities

People

  • Michael Bennett

Organizations

  • University of Texas Southwestern Medical Center

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Cells
  • Bone Marrow Cells
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Cultured Cells
  • Leukocytes
  • Lymphatic Diseases
  • Lymphatic System
  • Lymphocytes
  • Molecules
  • Neoplasms
  • Peptide Growth Factors
  • Proteins

Fields of Study

  • Chemistry
  • Medicine

Readers

  • Immunology