Cell-Cell Adhesion and Insulin-Like Growth Factor I Receptor in Breast Cancer

Abstract

This is a final report of the research carried out between 8/15/1997 and 8/14/2001. Our goal was to study the role of the insulin-like growth factor I receptor (IGF-IR) in breast cancer. The IGF-IR is a multifunctional tyrosine kinase that has been recently implicated in breast tumor development and progression. The IGF-IR is often overexpressed in estrogen receptor (ER)-positive breast tumors and this feature predicts enhanced tumor drug- and radio-resistance and cancer recurrence at the primary site. Our research demonstrated that the IGF-IR induces cell survival, growth and estrogen-independence in hormone-sensitive cells.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADA398204

Entities

People

  • Ewa Surmacz
  • Monica Bartucci

Organizations

  • Thomas Jefferson University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Membrane Structures
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Cytoskeleton
  • Health Services
  • Intercellular Junctions
  • Proteins
  • Three Dimensional
  • Tumor Cell Line

Readers

  • Breast cancer cell signaling and growth regulation.