Interleukin-6 and Prostate Cancer Progression
Abstract
In the current work we are exploring the hypothesis that interleukin-6 (IL-6) contributes to the progression of prostate cancer (PCA) through enhancing AR activity. Objective I is to determine the mechanism through which IL-6 sensitizes AR to androgen. We have determined that IL-6 induces AR expression through stimulation of the AR gene promoter. Furthermore, IL-6 enhances AR activity in the absence of androgen. Objective II is to evaluate if inhibition of IL-6 diminishes PCA proliferation in a rodent model. We have determined that administration of anti-IL-6 antibody induces regression of established PC- 3 PCA cell line tumors in a murine xenograft model through induction of apoptosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA398242
Entities
People
- Evan T Keller
Organizations
- University of Michigan