Development of a Biologic Basis for PSMA Targeting in Prostate Cancer
Abstract
We are going to define the biology of PSMA in order to enhance our ability to use PSMA as a target and to generate anti-tumor agents that will be specific and selective for PSMA protein. There is a PSMA-like protein that is similar to PSMA. We will identify that protein so we can develop agents that will be selective for the prostate PSMA protein. We want to know whether the binding of drugs that bind to PSMA are transported into the tumor or whether they stay at the cell surface as it will alter the strategy for drug development. We are going to develop potential ligands (drugs or molecules that bind to PSMA) that will serve as a guide to the chemicals that bind to the active site of enzymatic activity of the PSMA, the "substrate pocket" to identify the 3D structure of the PSMA. The identification of the 3D structure of the PSMA will greatly enhance the potential for rapid development of selective agents. We will also use phage display to identify small peptide ligands that could service as drug delivery vehicles and to aid to identify ligands that will differentiate between PSMA and PSMA-like protein.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2001
- Accession Number
- ADA398283
Entities
People
- Warren D. Heston