Red Blood Cell Storage Laboratory
Abstract
The Bionetics Corporation staffed and maintained laboratories to support red blood cell preservation and pathogen inactivation research for the Blood Research Detachment and Department, Walter Reed Army Institite of Research Building 503 Walter Reed Forest Glen Annex, Silver Spring, MD 20910. Contract staff completed three in vitro trials with another three are in progress at the conclusion of the reporting period. The three completed trials evaluated the effects on red cell storage of 1) incremental changes in salt and 2) phosphate content of the storage solution and the 3) incremental pH adjustment of the anticoagulant into which the blood was collected. The results of the three trials indicate potential for optimizing existing storage solutions. Two of three trials in progress are evaluations of separate pathogen inactivation processes. The first is to measure the effects of treatment on red cell storage; the second is to determine the ability of riboflavin to inactivate Plasmodium falciparum in red cells. The third trial in progress is designed to provide data on a process improvement for the processing of frozen red cells. Data from our laboratory resulted in four published manuscripts, a fifth has been accepted. The Bionetics Corporation advanced the WRAIR Blood Research mission.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA398358
Entities
People
- Lloyd E. Lippert