Alcohol and Adaptation to Mechanical Usage
Abstract
These studies are designed to determine whether ethanol antagonizes the ability of the skeleton to adapt to increased mechanical usage. Ethanol reversibly alters the biophysical properties of cell membranes. The overall hypothesis to be tested in adult rats is that these membrane changes disrupt essential cell signaling pathways for one or more cytokines, growth factors and polypeptide hormones that regulate bone modeling and remodeling. This report summarizes our progress from 0l September 2000 to 31 August 2001. During Year 3 of the award we have continued analysis of experiments performed in Year 2 related to Tasks 7 and 8. Additional experiments were performed to accomplish Task 6. The new studies are directed toward determination of the effects of ethanol on: the skeletal response to unloading (Task 6), skeletal adaptation to treadmill running (Task 7), and PTH-induced increases in mRNA levels for bone matrix proteins (Task 8). The results to date strongly support our hypothesis that alcohol abuse contributes to skeletal injuries suffered during the course of rigorous physical training activities.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA398383
Entities
People
- Russell T Turner