ErbB2 Regulation of c-src Activity in Breast Cancer
Abstract
Overexpression of ErbB2 in mammary epithelial cells increases activity, but not expression, of c-src. This effect is not mimicked by other transforming oncogenes. These results suggest that previous results in transgenic animals are likely to be due to direct effects on mammary epithelium, not to alterations in systemic physiology (such as hormone levels) or to altered epithelial stromal interactions. Results indicate that induction of c-src activity is mediated by increased activity of a src-directed phosphatase that removes an inhibitory phosphate at Y527. SHP2 appears to be a leading candidate for the phosphatase. In addition, the activation of c-src by ErbB2 appears to play a critical role in inducing a tumor phenotype. These results that strategies to modify src activity or the activity of the src-directed phosphatase(s) may prove useful in modifying tumor progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2001
- Accession Number
- ADA398670
Entities
People
- Lewis G. Sheffield
Organizations
- University of Wisconsin–Madison