The Role of a LIM Only Factor, LMO-4 in Breast Cancer
Abstract
We recently identified a novel transcription factor, LMO-4, which exhibits prominent expression in epithelial cells, including that of the breast. Since previous members of the LIM only (LMO) gene family are oncogenes in lymphocytes, we hypothesized that LMO-4 may play a role in mammary gland development and cancer. To test this prediction, we are in the process of: (1) Defining more precisely the expression of LMO-4 during mammary gland development and in human breast cancer, (2) Analyzing transgenic mice which we have created to alter the activity of LMO-4 in mammary glands, and (3) Cloning DNA-binding protein with which LMO-4 interacts. We have found that LMO-4 is primarily expressed in the mammary gland during a stage when epithelial cells are proliferating in preparation for lactation. In addition, est databases show that LMO-4 is highly expressed in human breast cancer. We have generated transgenic lines for analyses and initiated cloning of LMO-4-interacting proteins. Our preliminary data suggest that expression of LMO-4 is associated with undifferentiated cellular stage, such as that found in breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2001
- Accession Number
- ADA398937
Entities
People
- Bogi Anderson
Organizations
- University of California, San Diego