Characterization of Putative Homeostatic Molecules in Prostate Development and Androgen-Independent Prostate Cancer

Abstract

Androgen-independent (AI) prostate cancer (PCa) is a life-threatening disease. No effective treatment is available for this disease because the biology of AIPCa is still unknown. It is known that AIPCa possesses many similar properties of the basal (or stem) cell in prostate. Therefore, in this project, we studied the signal pathway(s) controlling growth/differentiation of basal cells of prostate. We focused on two unique molecules, C-CAM1 and DOC-2, because both proteins often loss their expression on PCa and are a potent growth inhibitor. For C-CAM1, we analyzed the functional domain of C-CAM1 that modulates its tumor suppression function.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2001
Accession Number
ADA399028

Entities

People

  • Jer-Tsong Hsieh

Organizations

  • University of Texas at Dallas

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Gene Expression
  • Genetic Structures
  • Medical Personnel
  • Molecules
  • Neoplasms
  • Papillomavirus Infections
  • Peptide Growth Factors
  • Prostate Cancer
  • Proteins

Readers

  • Molecular Biology and Genetics
  • Prostate Cancer Biology.

Technology Areas

  • Biotechnology