Low-Level Sarin Neurotoxicity and Its Modulation by Pyridostigmine

Abstract

The possibility that a combination of exposure to organophosphate esters (OPs) and the carbamate pyridostigmine bromide (PB) led to neurological symptoms (claimed to a low-grade organophosphate induced delayed neuropathy, OPIDN) in Gulf War veterans is under experimental study. Animals (hen, mouse) are treated with diisopropyl fluorophosphate (DFP) or sarin (GB) in the presence or absence of PB. We established subthreshold and threshold levels for the induction of OPIDN in hens repeatedly treated with TOCP or DFP. Preliminary findings suggest increased nerve damage when DFP-treated hens are concurrently treated with PB. In the mouse, large single doses of TOCP failed to induce clinical or pathological signs of OPIDN.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2001
Accession Number
ADA399150

Entities

People

  • Barry W. Wilson

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Autonomic Nervous System
  • Biomedical Research
  • Blood
  • Body Weight
  • Brain
  • Cells
  • Central Nervous System
  • Chemistry
  • Nerve Fibers
  • Nerves
  • Nervous System
  • Neurons
  • Neuropathy
  • Peripheral Nervous System
  • Sciatic Nerve
  • Spinal Cord

Readers

  • Neurotoxicology
  • Toxicology/Environmental Toxicology