Analysis of Investigational Drugs in Biological Fluids - Method Development and Analysis of Pre-Clinical Samples

Abstract

Work on development and/or validation of analytical methodologies during the current contract focused on assays for WR 6026 (and its metabolites, WR 211789 and WR 254421), mefloquine (and its metabolite, WR 160972), p-aminoheptanophenone (and related compounds), WR 242511, halofantrine (and its metabolite, WR 178,460, and their stereoisomers), chloroquine (and its metabolites, monodesethylchoroquine and didesethyichloroquine), WR 243,251, WR 238,605, gentamicin, paromomycin and artelinic acid (and metabolites and artesunate). Work on routine analyses of biological specimens during this period was performed for studies that required determination of concentrations of artelinic acid, choroquine (and its metabolites, monodesethyichloroquine and didesethylchloroquine), and stereoisomers of halofantrine (and its metabolite, WR 178,460).

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2001
Accession Number
ADA399915

Entities

People

  • Emil T. Lin

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Accuracy
  • Alcohols
  • Blood
  • Chemistry
  • Chlorides
  • Detection
  • Detectors
  • Hydroxides
  • Infection
  • Liquid Chromatography
  • Mass Spectrometry
  • Medical Personnel
  • Optical Detectors
  • Pharmaceutical Preparations
  • Quality Control
  • Ultraviolet Detection
  • Water

Fields of Study

  • Chemistry

Readers

  • Parasitology and Pharmacology of Malaria.